This is a phase I study that is testing various injection methods for giving the vaccines. In this study they will be using two different study vaccines (and no placebos) that have been given to more than 100 people in studies before. People eligible for this study, will be assigned to one of three groups. People in all groups will get three injections of the study vaccines into the muscle of their arm. People in Group 1 will get an injection into the muscle in their arm. People in Group 2 will get an injection between the layers of their skin of their arm. People in Group 3 will get an injection under their skin of their arm. All three ways of giving the injection have been used for giving other vaccines. You will be assigned to a group at random, like the toss of a coin. You have a 1-in-3 chance of being in any one of the groups. You and the researchers will know which group you are in. To date, the vaccines have been well tolerated with only a few expected side effects. The vaccines do not contain live or killed HIV, so there is NO possibility of getting HIV from them. There will be 15-20 people in this study here in Seattle. A total of about 90 people will take part at all participating sites. Enrollment for this study will start in mid-Novembember. We will be looking for men and women, HIV-negative, 18-50 years old and in general good health. We also require volunteers to have stable living situations in the general Seattle area for the duration of the study. This study will be 12 months long and will have approximately 11 visits. Enrollment for this study is complete.

This phase II study will be testing the same product used in the Step Study (see below). This vaccine has been tested in over 1300 people in the United States as well as over 700 people outside of the United States.  To date, the vaccine has been generally well-tolerated.  The vaccine has also been tested in animals with no serious side effects.  The vaccine is made in a laboratory.  The purpose of this study is to test various dosages. This study will not use a placebo because it has been used in other studies. This study will be 9 months long and requires volunteers to be vaccinated at 3 different visits. This study will be looking for volunteers who are low risk of getting HIV. We are looking for men and women who are 18-50 years old, HIV negative and in general good health. Volunteers who are eligible for this study will have had no more than 4 sexual partners in the last 6 months, no history of sexually transmitted diseases, no unprotected sexual contact with more than one partner. Other eligibility requirements will be discussed at screening. There will be a total of about 204 people in this study.  We plan to enroll 10-15 volunteers at this site.  We need volunteers who are committed to coming in once or twice a month. Enrollment for this study is complete.

Can HIV infection be prevented? Can HIV levels in the blood be reduced? Help scientists test an investigational HIV vaccine. This study has completed enrollment. Click here to learn more.